Synthesis of new series of Pyrazoline, and study their Kinetics and Reaction Mechanism

Kaka, Kosrat N. and Taher, Salam G. and Hamad, Wali M. and Ibrahim, Aram H. (2019) Synthesis of new series of Pyrazoline, and study their Kinetics and Reaction Mechanism. ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY, 7 (2). pp. 5-13. ISSN 2410-9355

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Abstract

A new series of novel pyrazoline compounds were synthesized by addition of thiosemicarbazide to the 2,6-dibenzylidenecyclohexanone (Chalcone) and its para substituted derivatives. This study was conducted for four purposes. Firstly, a series of five membered ring pyrazoline compounds were synthesized and the structure of all new products obtained are supported by spectral data (1H-NMR, 13CNMR, IR and UV-Vis.), and the effect of substituents were studied. Secondly, the reaction kinetics of the new synthesized compounds were studied to investigate the reaction mechanism pathway and order of the reaction; it was found that, the reaction undergoes via Claisen route of mechanism with first-order reaction. Thirdly, the thermodynamics of the reaction were studied, the rate of the reaction, Arrhenius parameters (A), and thermodynamic parameters for activation includes (free energies (Ea), entropies (ΔS#), and Gibbs free energy (ΔG#) were estimated. Finally, the compensation effect was also studied, and found the same pathway for all of the synthesized pyrazoline compounds.

Item Type:	Article
Uncontrolled Keywords:	Pyrazolines, Kinetics, Mechanism, Chalcones, Compensation effect, Thiosemicarbazide, Claisen and Michael Pathway.
Subjects:	Q Science > QD Chemistry
Divisions:	ARO-The Scientific Journal of Koya University > VOL 7, NO 2 (2019)
Depositing User:	Dr Salah Ismaeel Yahya
Date Deposited:	19 Mar 2020 20:02
Last Modified:	30 Mar 2020 22:33
URI:	http://eprints.koyauniversity.org/id/eprint/196

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