New Thiazole Derivatives

Omer, Rebaz A. and Ahmed, Karzan M. and Othman, Khdir A. and Hamad, Wali M. and Faraj, Rahman K. and Muhialdin, Ali J. and Salih, Shalaw K. (2024) New Thiazole Derivatives. ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY, 12 (2). pp. 10-22. ISSN 2410-9355

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Abstract

While bacterial superbugs have garnered much attention, the rise of antifungal resistance poses a growing threat. This study explores the potential of newly synthesized 2,5-Bis(3,4 Dialkoxy Phenyl) Thiazolo[5,4-d] Thiazoles (DATTn compounds) as antifungal agents. Notably, DATTn compounds demonstrated significant fungicidal activity against Candida albicans, a major fungal pathogen, whereas remaining largely ineffective against common bacterial strains, such as Staphylococcus aureus and Escherichia coli. In silico docking simulations using Schrödinger suites unveiled the molecular basis for this selectivity, revealing strong interactions between DATTn molecules and a crucial fungal protein (Portion Data Bank ID: 8JZN) in C. albicans. These findings highlight the potential of DATTn compounds as promising leads for the development of novel antifungal therapies, particularly in light of escalating drug resistance concerns.

Item Type:	Article
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Uncontrolled Keywords:	Antifungal activity, Bacterial resistance, Candida albicans, DATTn compounds, Drug discovery, Molecular docking
Subjects:	Q Science > QD Chemistry
Divisions:	ARO-The Scientific Journal of Koya University > VOL 12, NO 2 (2024)
Depositing User:	Dr Salah Ismaeel Yahya
Date Deposited:	07 May 2025 08:32
Last Modified:	07 May 2025 08:32
URI:	http://eprints.koyauniversity.org/id/eprint/495

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